Preclinical imaging of the cellular and molecular events in the multistep process of bone metastasis

Future Oncol. 2012 Apr;8(4):415-30. doi: 10.2217/fon.12.33.


Bone metastasis is a complex process that ultimately leads to devastating metastatic bone disease. It is therefore of key interest to unravel the mechanisms underlying the multistep process of skeletal metastasis and cancer-induced bone disease, and to develop better treatment and management of patients with this devastating disease. Fortunately, novel technologies are rapidly emerging that allow real-time imaging of molecules, pathogenic processes, drug delivery and drug response in preclinical in vivo models. The outcome of these experimental studies will facilitate clinical cancer research by improving the detection of cancer cell invasion, metastasis and therapy response.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / secondary*
  • Diagnostic Imaging / methods*
  • Disease Models, Animal
  • Disease Progression
  • Humans
  • Molecular Imaging / methods
  • Neoplasm Metastasis / diagnosis