The many faces of nickel allergy

Int J Dermatol. 2012 May;51(5):523-30. doi: 10.1111/j.1365-4632.2011.05233.x.


Hypersensitivity reactions to nickel are one of the most common in the modern world. Nickel allergy prevalence is constantly growing in many countries and represents a major health and socioeconomic issue. Herein the current understanding on nickel allergy is summarized with a practical approach to the dermatologist, allergist, and general practitioner. The personal experience with some practical clinical cases of nickel dermatitis is shared. A special emphasis is put on the possible strategies for treatment and prevention of the disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Dermatitis, Allergic Contact / diagnosis*
  • Dermatitis, Allergic Contact / epidemiology
  • Dermatitis, Allergic Contact / etiology
  • Dermatitis, Allergic Contact / therapy*
  • Female
  • Humans
  • Male
  • Nickel / adverse effects*
  • Nickel / immunology
  • Risk Factors


  • Nickel