Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling

Dev Cell. 2012 Apr 17;22(4):695-702. doi: 10.1016/j.devcel.2012.03.013.

Abstract

Over the past decade, the Hippo tumor suppressor pathway has emerged as a central regulator of growth in epithelial tissues. Research in Drosophila and in mammals has shown that this kinase signaling cascade regulates the activity of the transcriptional coactivator and oncoprotein Yorkie/Yap. In this review, we discuss recent findings that emphasize the cell cortex-specifically the actin cytoskeleton, intercellular junctions, and protein complexes that determine cell polarity-as a key site for Hippo pathway regulation. We also highlight where additional research is needed to integrate known functional interactions between Hippo pathway components.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Communication*
  • Cell Polarity*
  • Cytoskeleton / metabolism*
  • Drosophila / growth & development*
  • Drosophila / metabolism*
  • Drosophila Proteins / metabolism*
  • Intercellular Junctions / physiology*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction

Substances

  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Protein-Serine-Threonine Kinases
  • hpo protein, Drosophila