Clinical approach to leukoencephalopathies

Semin Neurol. 2012 Feb;32(1):29-33. doi: 10.1055/s-0032-1306383.


Recent advances in biochemical and molecular genetics have led to the discovery of new leukoencephalopathies. Despite these advances, many patients with leukoencephalopathy remain undiagnosed. A systematic approach to the investigation of these patients is needed to select the most appropriate testing strategy. In this article, the author presents a clinical and magnetic resonance imaging (MRI) based approach to the evaluation of patients with leukoencephalopathy.

Publication types

  • Review

MeSH terms

  • Brain / pathology
  • Humans
  • Leukoencephalopathies / diagnosis*
  • Leukoencephalopathies / metabolism
  • Magnetic Resonance Imaging*
  • Myelin Sheath / pathology
  • Physical Examination