Polyglucosan bodies in sural nerve biopsies

Acta Neuropathol. 1990;80(5):554-7. doi: 10.1007/BF00294618.

Abstract

The presence of polyglucosan bodies in sural nerves collected over a 16-year period was studied in relation to age, sex, presence of polyneuropathy, and concomitant presence of central nervous system disorder. Polyglucosan bodies have been seen in only one patient without a polyneuropathy. This patient was suffering from Lafora's disease. In all other sural nerves positive for polyglucosan bodies a polyneuropathy was present. Within this group the prevalence of polyglucosan bodies was positively correlated with age, and if a central nervous system disorder was associated, this prevalence was more distinct. With semiquantitative measurements of the surface of polyglucosan bodies a significant correlation was found between age and percentage of large bodies.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Biopsy
  • Child
  • Child, Preschool
  • Female
  • Glucans / analysis*
  • Humans
  • Male
  • Middle Aged
  • Nervous System Diseases / pathology*
  • Retrospective Studies
  • Sural Nerve / pathology*

Substances

  • Glucans