Renal oncocytoma growth rates before intervention

BJU Int. 2012 Nov;110(10):1444-8. doi: 10.1111/j.1464-410X.2012.011136.x. Epub 2012 Apr 23.


Objective: To describe the growth rates of oncocytomas before treatment with surgical resection or percutaneous ablation.

Patients and methods: This single-institution retrospective study included 33 consecutive, pathologically proven renal oncocytomas with serial contrast-enhanced computed tomography scans spanning at least 1 year before intervention, from 2000 to 2009. Tumours were measured by two radiologists, and growth rates and interobserver variability were calculated. The mean (range) pre-procedural imaging surveillance period was 36 (12-124) months (median 33 months).

Results: The mean (SD) oncocytoma size was 17 (11) mm (range 4-47 mm, median 15 mm) in maximum transverse diameter on initial imaging and grew to a mean (SD) of 26 (5) mm (range 10-83 mm, median 23 mm) by the time of treatment. Overall, the mean (SD) and median growth rates were 2.9 (2.6) mm/year and 2.7 mm/year, respectively (range -1.2-10.9 mm/year). After weighting by the se of each tumour's growth rate, the mean (SD) change was 2.1 (1.2) mm/year. The mean (range) interobserver variability for each tumour measurement was 1 (0-7) mm with an intraclass correlation coefficient of 0.99.

Conclusions: Renal oncocytomas grow at a rate similar to reported growth rates of renal cell carcinoma. As the observation of growth does not distinguish between benign and malignant renal tumours, growth of small renal masses under active surveillance should be carefully considered before a switch is made to intervention.

MeSH terms

  • Adenoma, Oxyphilic / diagnosis
  • Adenoma, Oxyphilic / diagnostic imaging
  • Adenoma, Oxyphilic / pathology*
  • Adenoma, Oxyphilic / surgery
  • Aged
  • Aged, 80 and over
  • Carcinoma, Renal Cell / diagnosis
  • Catheter Ablation
  • Cryosurgery
  • Diagnosis, Differential
  • Female
  • Humans
  • Kidney Neoplasms / diagnosis
  • Kidney Neoplasms / diagnostic imaging
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / surgery
  • Laparoscopy
  • Male
  • Middle Aged
  • Nephrectomy
  • Tomography, X-Ray Computed

Supplementary concepts

  • Oncocytoma, renal