Actin' as a death signal

Immunity. 2012 Apr 20;36(4):557-9. doi: 10.1016/j.immuni.2012.04.004.


Cell death needs to be detected by immune cells. In this issue of Immunity, Ahrens et al. (2012) and Zhang et al. (2012) show that actin filaments become exposed on necrotic cells and act as ligands for the C-type lectin receptor Clec9a.

Publication types

  • Comment