Review on Labisia pumila (Kacip Fatimah): bioactive phytochemicals and skin collagen synthesis promoting herb

Fitoterapia. 2012 Dec;83(8):1322-35. doi: 10.1016/j.fitote.2012.04.002. Epub 2012 Apr 10.


Labisia pumila is a traditional herb widely used as post-partum medication for centuries. Recently, extensive researches have been carried out on the phytochemical identification, biological and toxicological studies for the herb. Phytochemicals found in the herbal extract showed high antioxidant properties, which were essential for various pharmacological activities. The significant findings are anti-estrogenic deficiency and -immunodeficiency diseases. Another finding that has considerable impact on natural product research is the contribution of L. pumila in promoting skin collagen synthesis. The performance of the herb as anti-aging agent due to natural aging process and accelerated by UV radiation was reviewed critically.

Publication types

  • Review

MeSH terms

  • Collagen / biosynthesis*
  • Estrogens / deficiency
  • Humans
  • Phytoestrogens / chemistry
  • Phytoestrogens / pharmacology
  • Phytotherapy
  • Primulaceae / chemistry*
  • Skin / drug effects*
  • Skin / metabolism*


  • Estrogens
  • Phytoestrogens
  • Collagen