Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig

Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1422-8. doi: 10.1164/ajrccm/142.6_Pt_1.1422.


To investigate the long-term effect of cigarette smoke on pulmonary structure and function, we exposed groups of guinea pigs to the smoke of 10 cigarettes each day, 5 days per week, for 1, 3, 6, and 12 months. We found that the guinea pigs developed progressive lung destruction (emphysema) and alterations in their pulmonary function tests similar to that seen in humans with cigarette smoke-induced chronic obstructive lung disease. This method of smoke-induced lung destruction should provide a good model for the study of the early changes of emphysema.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Guinea Pigs
  • Lung / pathology
  • Lung / physiopathology
  • Lung Volume Measurements
  • Plants, Toxic*
  • Pulmonary Emphysema / etiology*
  • Pulmonary Emphysema / pathology
  • Pulmonary Emphysema / physiopathology
  • Smoke / adverse effects*
  • Time Factors
  • Tobacco*


  • Smoke