Clinical research informatics: a conceptual perspective
- PMID: 22523344
- PMCID: PMC3392857
- DOI: 10.1136/amiajnl-2012-000968
Clinical research informatics: a conceptual perspective
Abstract
Clinical research informatics is the rapidly evolving sub-discipline within biomedical informatics that focuses on developing new informatics theories, tools, and solutions to accelerate the full translational continuum: basic research to clinical trials (T1), clinical trials to academic health center practice (T2), diffusion and implementation to community practice (T3), and 'real world' outcomes (T4). We present a conceptual model based on an informatics-enabled clinical research workflow, integration across heterogeneous data sources, and core informatics tools and platforms. We use this conceptual model to highlight 18 new articles in the JAMIA special issue on clinical research informatics.
Conflict of interest statement
Figures
Similar articles
-
Translational informatics: enabling high-throughput research paradigms.Physiol Genomics. 2009 Nov 6;39(3):131-40. doi: 10.1152/physiolgenomics.00050.2009. Epub 2009 Sep 8. Physiol Genomics. 2009. PMID: 19737991 Free PMC article. Review.
-
Crossing the chasm: information technology to biomedical informatics.J Investig Med. 2011 Jun;59(5):768-79. doi: 10.2310/JIM.0b013e31821452bf. J Investig Med. 2011. PMID: 21383632 Free PMC article.
-
Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.Methods Mol Biol. 2021;2194:1-19. doi: 10.1007/978-1-0716-0849-4_1. Methods Mol Biol. 2021. PMID: 32926358
-
Translational Bioinformatics and Clinical Research (Biomedical) Informatics.Surg Pathol Clin. 2015 Jun;8(2):269-88. doi: 10.1016/j.path.2015.02.015. Epub 2015 Mar 31. Surg Pathol Clin. 2015. PMID: 26065800 Review.
-
The Global Health Informatics landscape and JAMIA.J Am Med Inform Assoc. 2023 Mar 16;30(4):775-780. doi: 10.1093/jamia/ocad024. J Am Med Inform Assoc. 2023. PMID: 36869748 Free PMC article. Review.
Cited by
-
Development and utility of a clinical research informatics application for participant recruitment and workflow management for a return of results pilot trial in familial hypercholesterolemia in the Million Veteran Program.JAMIA Open. 2024 Mar 8;7(1):ooae020. doi: 10.1093/jamiaopen/ooae020. eCollection 2024 Apr. JAMIA Open. 2024. PMID: 38464744 Free PMC article.
-
Informing training needs for the revised certified clinical data manager (CCDMTM) exam: analysis of results from the previous exam.JAMIA Open. 2022 Feb 22;5(1):ooac010. doi: 10.1093/jamiaopen/ooac010. eCollection 2022 Apr. JAMIA Open. 2022. PMID: 35274085 Free PMC article.
-
Natural Language Processing and Machine Learning for Identifying Incident Stroke From Electronic Health Records: Algorithm Development and Validation.J Med Internet Res. 2021 Mar 8;23(3):e22951. doi: 10.2196/22951. J Med Internet Res. 2021. PMID: 33683212 Free PMC article.
-
The maturation of clinical research informatics as a subdomain of biomedical informatics.J Am Med Inform Assoc. 2021 Jan 15;28(1):1-2. doi: 10.1093/jamia/ocaa312. J Am Med Inform Assoc. 2021. PMID: 33450764 Free PMC article. No abstract available.
-
The REDCap consortium: Building an international community of software platform partners.J Biomed Inform. 2019 Jul;95:103208. doi: 10.1016/j.jbi.2019.103208. Epub 2019 May 9. J Biomed Inform. 2019. PMID: 31078660 Free PMC article.
References
Publication types
MeSH terms
Grants and funding
- R01 HS019853/HS/AHRQ HHS/United States
- R01LM009886/LM/NLM NIH HHS/United States
- R01LM010815/LM/NLM NIH HHS/United States
- R21 HS019726/HS/AHRQ HHS/United States
- R01 HS019908/HS/AHRQ HHS/United States
- R01HS019908/HS/AHRQ HHS/United States
- UL1RR024156/RR/NCRR NIH HHS/United States
- R01HS019853/HS/AHRQ HHS/United States
- UL1 RR025780/RR/NCRR NIH HHS/United States
- UL1 RR024156/RR/NCRR NIH HHS/United States
- R01 LM009886/LM/NLM NIH HHS/United States
- R21 HS19726-01A/HS/AHRQ HHS/United States
- R01 LM010815/LM/NLM NIH HHS/United States
