Clinical implications of thyroid hormones effects on nervous system development

Pediatr Endocrinol Rev. 2012 Mar;9(3):644-9.


Thyroid hormones have an important role throughout prenatal and postnatal nervous system development. They are involved in several processes such as neurogenesis, gliogenesis, myelination, synaptogenesis, etc., as shown in many cases of deficiency like congenital hypothyroidism or hypothyroxinemia. Those pathologies if untreated could lead to severe damages in cognitive, motor, neudoendocrine functions among other effects. Some could be reversed after adequate supplementation of thyroid hormones at birth, however there are other cellular processes highly sensitive to low levels of thyroid hormones and lasting a limited period of time during which if thyroid hormone action is lacking or deficient, the functional and structural damages would produce permanent defects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • Humans
  • Infant, Newborn
  • Nervous System / embryology*
  • Nervous System / growth & development*
  • Nervous System Diseases / physiopathology*
  • Thyroid Diseases / physiopathology*
  • Thyroid Hormones / physiology*


  • Thyroid Hormones