Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma

Pigment Cell Melanoma Res. 2012 Jul;25(4):506-13. doi: 10.1111/j.1755-148X.2012.01008.x. Epub 2012 Jun 1.

Abstract

Genetic variants of NLRP3 and NLRP1 are known to modulate levels of pro-inflammatory cytokine interleukin (IL)-1β. The purpose of this study was to investigate the association of NLRP3/NLRP1 polymorphisms with susceptibility and clinical features of malignant melanoma in a Swedish case-control study. Common variants in NLRP3/NLRP1 were investigated in sporadic malignant melanoma patients and healthy controls followed by analysis using logistic regression. NLRP3 variant (rs35829419) was significantly more common in male patients than in controls (OR, 2.22; CI, 1.27-3.86). Upon stratification, significant association with nodular melanoma was observed (OR, 2.89; CI, 1.33-6.30), which intensified in male patients (OR 4.03, CI 1.40-11.59). The NLRP1 variant (rs12150220) was significantly more common in fair-skinned female patients (OR, 1.85; CI, 1.04-3.33) and showed strong associations with nodular melanoma (OR, 6.03; CI, 1.33-25). Our data suggest that NLRP3/NLRP1 polymorphisms are associated with melanoma susceptibility; these findings warrant validation in other independent populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Apoptosis Regulatory Proteins / genetics*
  • CARD Signaling Adaptor Proteins / genetics
  • Carrier Proteins / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Inflammasomes / genetics*
  • Interleukin-18 / metabolism
  • Interleukin-1beta / metabolism
  • Male
  • Melanoma / genetics*
  • Middle Aged
  • Models, Biological
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Neoplasm Proteins / genetics
  • Phenotype
  • Polymorphism, Single Nucleotide / genetics*
  • Skin Neoplasms / genetics*

Substances

  • Adaptor Proteins, Signal Transducing
  • Apoptosis Regulatory Proteins
  • CARD Signaling Adaptor Proteins
  • CARD8 protein, human
  • Carrier Proteins
  • Inflammasomes
  • Interleukin-18
  • Interleukin-1beta
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP1 protein, human
  • NLRP3 protein, human
  • Neoplasm Proteins