Phthalide and isocoumarin derivatives produced by an Acremonium sp. isolated from a mangrove Rhizophora apiculata

Vatcharin Rukachaisirikul; Aekkachai Rodglin; Yaowapa Sukpondma; Souwalak Phongpaichit; Jirayu Buatong; Jariya Sakayaroj

doi:10.1021/np200885e

Phthalide and isocoumarin derivatives produced by an Acremonium sp. isolated from a mangrove Rhizophora apiculata

J Nat Prod. 2012 May 25;75(5):853-8. doi: 10.1021/np200885e. Epub 2012 Apr 23.

Authors

Vatcharin Rukachaisirikul¹, Aekkachai Rodglin, Yaowapa Sukpondma, Souwalak Phongpaichit, Jirayu Buatong, Jariya Sakayaroj

Affiliation

¹ Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University , Hat Yai, Songkhla 90112, Thailand. vatcharin.r@psu.ac.th

PMID: 22524636
DOI: 10.1021/np200885e

Abstract

Nine new fungal metabolites, one phthalide derivative, acremonide (1), and eight isocoumarin derivatives, acremonones A-H (2-9), were isolated from the mangrove-derived fungus Acremonium sp. PSU-MA70 together with 10 known compounds. Their structures were determined by NMR analysis. The known 8-deoxytrichothecin and trichodermol exhibited moderate antifungal activity against Candida albicans and Cryptococcus neoformanns, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acremonium / chemistry*
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification
Benzofurans / chemistry
Benzofurans / isolation & purification*
Candida albicans / drug effects
Cryptococcus neoformans / drug effects
Isocoumarins / chemistry
Isocoumarins / isolation & purification*
Microbial Sensitivity Tests
Molecular Structure
Rhizophoraceae / microbiology*
Thailand

Substances

Antifungal Agents
Benzofurans
Isocoumarins
acremonide
phthalide