Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways

Semin Cell Dev Biol. 2012 Sep;23(7):794-802. doi: 10.1016/j.semcdb.2012.04.001. Epub 2012 Apr 15.


Over the past decade Hippo kinase signalling has been established as an essential tumour suppressor pathway controlling tissue growth in flies and mammals. All members of the Hippo core signalling cassette are conserved from yeast to humans, whereby the yeast analogues of Hippo, Mats and Lats are central components of the mitotic exit network and septation initiation network in budding and fission yeast, respectively. Here, we discuss how far core Hippo signalling components in Drosophila melanogaster and mammals have reported similar mitotic functions as already established for their highly conserved yeast counterparts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division*
  • G2 Phase*
  • Humans
  • Protein-Serine-Threonine Kinases / metabolism
  • RNA Polymerase III / metabolism
  • Signal Transduction*
  • Transcriptional Elongation Factors / metabolism
  • Yeasts / cytology*
  • Yeasts / metabolism*


  • Transcriptional Elongation Factors
  • Protein-Serine-Threonine Kinases
  • RNA Polymerase III