Effect of Methylsulfonylmethane Supplementation on Exercise - Induced Muscle Damage and Total Antioxidant Capacity

J Sports Med Phys Fitness. 2012 Apr;52(2):170-4.

Abstract

Aim: The aim of this study was to evaluate effect of 10-day methylsulfonylmethane (MSM) supplementation on exercise-induced muscle damage.

Methods: Eighteen healthy, non-smoking, active young men were recruited to participate in this study. Participants were randomized in a double-blind placebo-controlled fashion into two groups: MSM (M) (N.=9) and placebo (P) (N.=9). Subjects consumed daily either placebo (200 mL water) or MSM supplement (50 mg/kg MSM in 200 mL water) for 10 days. Afterward, participants ran 14 km. Blood samples were taken before supplementation, before exercise, immediately, 30 min, 2, 24 and 48 h after exercise.

Results: CK and bilirubin significantly increased in P group 24 h after exercise compared to M group (P=0.041 and P=0.002, respectively). TAC increased immediately post, 30 min, 2 and 24 h after exercise just in M group (P<0.05). TAC showed significant increase in M group 2 and 24 h after exercise compared to P group (P=0.014 and P=0.033, respectively).

Conclusion: It seems that 10-day supplementation with MSM has allowed to decrease muscle damage via effect on antioxidant capacity.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antioxidants / administration & dosage
  • Antioxidants / metabolism
  • Antioxidants / pharmacology*
  • Bilirubin / blood
  • Creatine Kinase / blood
  • Dietary Supplements*
  • Dimethyl Sulfoxide / administration & dosage
  • Dimethyl Sulfoxide / pharmacology*
  • Double-Blind Method
  • Exercise / physiology*
  • Humans
  • Male
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / injuries*
  • Muscle, Skeletal / physiology
  • Running / injuries
  • Running / physiology
  • Sulfones / administration & dosage
  • Sulfones / pharmacology*
  • Young Adult

Substances

  • Antioxidants
  • Sulfones
  • dimethyl sulfone
  • Creatine Kinase
  • Bilirubin
  • Dimethyl Sulfoxide