In the present study, the effect of organic pollution on land snails Eobania vermiculata was investigated. Five pollution biomarkers (neutral red retention assay, morphometry of lysosomes and neutral lipids, acetylcholinesterase activity and metallothioneins content), were applied on tissues of the land snails. The results showed intense differentiations between the snails treated with organic pollutants and the control ones, as indicated by the results obtained. Statistically significant correlations among the results obtained emphasize the usefulness of these biomarkers.