Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucifera L

Inflammopharmacology. 2013 Feb;21(1):31-5. doi: 10.1007/s10787-012-0135-7. Epub 2012 Apr 17.

Abstract

Cocos nucifera L. (family: arecaceae) is generally straight unbranched plant, traditionally cultivated for its fruit (coconut) in home gardens. In the present study, anti-inflammatory and antinociceptive (analgesic) activity of hydromethanol extract of Cocos nucifera L. (HECN) was evaluated in animal models. HECN showed significant (p < 0.05) and dosedependent anti-inflammatory activity in carrageenan induced paw oedema models of inflammation and the result was comparable with the standard drug diclofenac. In addition, the extract also showed highly significant (p < 0.01) antinociceptive activity. HECN treated group showed increase in the reaction time in hot plate method and decrease the writhing induced by acetic acid in mice when compared with control group animal. The anti-inflammatory and antinociceptive activity observed in the present study could be attributed largely to the presence of its antioxidant phytoconstituents such as flavonoid, saponin and polyphenols.

Publication types

  • Comparative Study

MeSH terms

  • Analgesics / administration & dosage
  • Analgesics / isolation & purification
  • Analgesics / pharmacology*
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Antioxidants / administration & dosage
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology
  • Cocos / chemistry*
  • Diclofenac / pharmacology
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Inflammation / drug therapy
  • Male
  • Mice
  • Pain / drug therapy
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Rats

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • Antioxidants
  • Plant Extracts
  • Diclofenac