Left-right asymmetry in zebrafish

Cell Mol Life Sci. 2012 Sep;69(18):3069-77. doi: 10.1007/s00018-012-0985-6. Epub 2012 Apr 19.


In vertebrates, internal organs are positioned asymmetrically across the left-right (LR) axis, placing them in a defined area within the body. This LR asymmetric placement is a conserved feature of the vertebrate body plan. Events determining LR asymmetry occur during embryonic development, and are regulated by the coordinated action of genetic mechanisms that are evolutionarily conserved among vertebrates. Recent studies using zebrafish have provided new insights into how the Kupffer's vesicle organizer region is generated, and how it relays LR asymmetry information to the lateral plate mesoderm. In this review, we summarize recent advances in zebrafish and describe our current understanding of the mechanisms underlying these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Patterning*
  • Embryo, Nonmammalian
  • Gene Expression Regulation, Developmental
  • Mesoderm
  • RNA, Messenger / metabolism
  • Signal Transduction
  • Zebrafish / embryology*
  • Zebrafish Proteins / genetics
  • Zebrafish Proteins / metabolism


  • RNA, Messenger
  • Zebrafish Proteins