ATP synthesis and storage

Purinergic Signal. 2012 Sep;8(3):343-57. doi: 10.1007/s11302-012-9305-8. Epub 2012 Apr 12.


Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell metabolism revolve around ATP production and consumption. It is important to understand the concepts of glucose and oxygen consumption in aerobic and anaerobic life and to link bioenergetics with the vast amount of reactions occurring within cells. ATP is universally seen as the energy exchange factor that connects anabolism and catabolism but also fuels processes such as motile contraction, phosphorylations, and active transport. It is also a signalling molecule in the purinergic signalling mechanisms. In this review, we will discuss all the main mechanisms of ATP production linked to ADP phosphorylation as well the regulation of these mechanisms during stress conditions and in connection with calcium signalling events. Recent advances regarding ATP storage and its special significance for purinergic signalling will also be reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphate / analysis
  • Adenosine Triphosphate / biosynthesis*
  • Adenosine Triphosphate / metabolism
  • Calcium / physiology
  • Calcium Signaling / physiology
  • Environment
  • Humans
  • Signal Transduction / physiology


  • Adenosine Triphosphate
  • Calcium