Hierarchical formation of supramolecular transient networks in water: a modular injectable delivery system

Adv Mater. 2012 May 22;24(20):2703-9. doi: 10.1002/adma.201104072. Epub 2012 Apr 23.

Abstract

A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Morphogenetic Protein 7 / metabolism
  • Drug Carriers / chemistry*
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry
  • Hydrogen Bonding
  • Myofibroblasts / metabolism
  • Polyethylene Glycols / chemistry
  • Water / chemistry*

Substances

  • Bone Morphogenetic Protein 7
  • Drug Carriers
  • Water
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Polyethylene Glycols