Bacteruria with group-B streptococcus: is it a risk factor for adverse pregnancy outcomes?

J Matern Fetal Neonatal Med. 2012 Oct;25(10):1983-6. doi: 10.3109/14767058.2012.671872. Epub 2012 Apr 25.


Objective: To investigate pregnancy outcomes of patients with and without group-B streptococcus (GBS) bacteriuria.

Methods: A retrospective study comparing pregnancy outcomes of women with GBS bacteriuria during pregnancy, those with positive GBS vaginal cultures and those without GBS colonization during pregnancy was conducted.

Results: A significant linear association was found with regard to intrapartum fever (U-GBS 0.5%, V-GBS 0.3%, no GBS 0.1%, p = 0.001) and chorioamnionitis (U-GBS 3.3%, V-GBS 1%, no GBS 0.7%, p = 0.001). In addition preterm delivery (15.3% vs. 7.9%, p = 0.001) and premature rupture of membranes (10.7% vs. 7.9, p = 0.001) were significantly higher in the U-GBS group compared to no GBS. Woman with U-GBS had higher rates of diabetes mellitus, hypertensive disorders, and habitual abortions as well as a higher risk for intrauterine growth restriction (IUGR). In addition patients with U-GBS underwent induction of labor and cesarean delivery more frequently.

Conclusions: Our study showed a significant association between U-GBS and adverse obstetrical outcomes. In addition a linear association was found between GBS culture location and obstetric complications. However, GBS was not associated with adverse perinatal outcome in our population.

MeSH terms

  • Adolescent
  • Adult
  • Bacteriuria* / diagnosis
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Fetal Membranes, Premature Rupture / microbiology
  • Humans
  • Linear Models
  • Logistic Models
  • Odds Ratio
  • Pregnancy
  • Pregnancy Complications, Infectious* / diagnosis
  • Pregnancy Outcome*
  • Premature Birth / microbiology
  • Retrospective Studies
  • Risk Factors
  • Streptococcal Infections* / diagnosis
  • Streptococcus agalactiae / isolation & purification*
  • Vagina / microbiology*
  • Young Adult