Phosphagen and lactate contents of m. quadriceps femoris of man after exercise

J Appl Physiol Respir Environ Exerc Physiol. 1977 Nov;43(5):852-7. doi: 10.1152/jappl.1977.43.5.852.


Muscle biopsies were taken from the m. quadriceps femoris of man immediately after termination of dynamic and isometric exercise. These were analyzed for adenosine triphosphate (ATP), adenosine 5'-diphosphate (ADP), adenosine 5'-phosphate (AMP), phosphorylcreatine (PC), creatine, pyruvate and lactate. Regardless of type, intensity, and duration of the preceding exercise, a general pattern of the relation between high-energy phosphates and lactate content could be observed. PG showed a nonlinear relationship to the muscle lactate content. The ratio of ATP to ADP appeared to decrease linearly when lactate content increased. The relationships are believed to be the consequence of a steady-state condition where muscle pH is one of the major determining factors.

MeSH terms

  • Adenine Nucleotides / metabolism*
  • Adenosine Diphosphate / metabolism
  • Adenosine Monophosphate / metabolism
  • Adenosine Triphosphate / metabolism*
  • Adolescent
  • Adult
  • Biopsy
  • Creatine / metabolism
  • Creatine Kinase / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Lactates / metabolism*
  • Male
  • Mathematics
  • Muscles / enzymology
  • Muscles / metabolism*
  • Physical Exertion*


  • Adenine Nucleotides
  • Lactates
  • Adenosine Monophosphate
  • Adenosine Diphosphate
  • Adenosine Triphosphate
  • Creatine Kinase
  • Creatine