Beneficial modulation from a high-purity caviar-derived homogenate on chronological skin aging

Rejuvenation Res. 2012 Apr;15(2):174-7. doi: 10.1089/rej.2011.1274.


This study tested the activity of LD-1227, which contains a caviar-derived homogenate added with coenzyme Q(10) (CoQ(10))-selenium component (CaviarLieri(®), Lab-Dom, Switzerland), in aged human skin and its potential role on skin mitochondria function. Human dermal fibroblasts were obtained from healthy donors over 70 years old and treated with LD-1227 for 72 hr. As compared to baseline, LD-1227 caused a robust (>67%) collagen type I synthesis (p<0.001) and decreased fibronectin synthesis (p<0.05) with significant fibronectin messenger RNA (mRNA) downregulation (p<0.05, r=0.78). A significant collagen mRNA overexpression occurred with LD-1227 treatment (p<0.05). Mitochondria cytosolic adenosine triphosphate (ATP) level decreased in aged skin samples (p<0.05 vs. young control), but this phenomenon was reversed by LD-1227 (p<0.01). These data show that LD-1227 may modify the extracellular matrix milieu in aged skin and also beneficially affect mitochondrial function.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Adult
  • Aged
  • Aging
  • Animals
  • Collagen / metabolism
  • Down-Regulation
  • Eggs
  • Extracellular Matrix / metabolism
  • Fibronectins / biosynthesis
  • Fish Products
  • Fishes
  • Humans
  • RNA, Messenger / metabolism
  • Skin Aging / drug effects*
  • Time Factors
  • Ubiquinone / analogs & derivatives
  • Ubiquinone / chemistry


  • Fibronectins
  • RNA, Messenger
  • Ubiquinone
  • Adenosine Triphosphate
  • Collagen
  • coenzyme Q10