Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Feb;39(1):18-26.
doi: 10.1016/j.ctrv.2012.03.006. Epub 2012 Apr 24.

Targeted Radio-Nuclide Therapy of Skeletal Metastases


Targeted Radio-Nuclide Therapy of Skeletal Metastases

Oliver Sartor et al. Cancer Treat Rev. .


In this review, we will focus on one particular class of stromal targeted therapy, i.e. the bone seeking radiopharmaceuticals (BSRs), but will also highlight selected issues related to the bone stroma as these concepts are new, rapidly evolving, and clearly linked to the underlying BSR mechanisms of targeting and action. Herein we review clinical BSR-trials of significance with randomized trials at center stage. Furthermore, we cover a new class of BSR in late clinical development based on bone-stromal targeted alpha-particle irradiation. Lastly, we discuss potential advances in combining BSR with bisphosphonates and/or chemotherapy and emphasize the feasibility of repeated dosing.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

MeSH terms


LinkOut - more resources