Targeted radio-nuclide therapy of skeletal metastases

Cancer Treat Rev. 2013 Feb;39(1):18-26. doi: 10.1016/j.ctrv.2012.03.006. Epub 2012 Apr 24.


In this review, we will focus on one particular class of stromal targeted therapy, i.e. the bone seeking radiopharmaceuticals (BSRs), but will also highlight selected issues related to the bone stroma as these concepts are new, rapidly evolving, and clearly linked to the underlying BSR mechanisms of targeting and action. Herein we review clinical BSR-trials of significance with randomized trials at center stage. Furthermore, we cover a new class of BSR in late clinical development based on bone-stromal targeted alpha-particle irradiation. Lastly, we discuss potential advances in combining BSR with bisphosphonates and/or chemotherapy and emphasize the feasibility of repeated dosing.

Publication types

  • Review

MeSH terms

  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / metabolism
  • Bone Neoplasms / secondary*
  • Bone Neoplasms / therapy
  • Drug Delivery Systems
  • Humans
  • Radionuclide Imaging
  • Radiopharmaceuticals / pharmacokinetics*
  • Radiopharmaceuticals / therapeutic use
  • Randomized Controlled Trials as Topic


  • Radiopharmaceuticals