Antidepressants and menstruation disorders in women: a cross-sectional study in three centers

Gen Hosp Psychiatry. 2012 Sep-Oct;34(5):529-33. doi: 10.1016/j.genhosppsych.2012.03.014. Epub 2012 Apr 24.


Objective: The relationship between menstruation disorders and antidepressant drugs usage in women remains unclear. In this study, we aimed to investigate the incidence rate of antidepressant-related menstruation disorders and to examine whether or not antidepressant use is associated with menstrual disorders in women.

Methods: The study sample was gathered from three centers and four hospitals. A total of 1432 women who met the criteria of inclusion were included in the study. The sample was divided into two groups: the antidepressant group (n=793) and the control group (n=639). The menstruation disorders were established with reports from the study participants on the basis of related gynecological descriptions.

Results: The prevalence of menstrual disorders was significantly higher in the antidepressant group (24.6%) than the control group (12.2%). The incidence of antidepressant-induced menstruation disorder was 14.5%. The antidepressants most associated with menstrual disorders were paroxetine, venlafaxine, sertraline and their combination with mirtazapine. Overall, the incidence rate was similar in women receiving selective serotonin reuptake inhibitors and serotonin noradrenaline reuptake inhibitors.

Conclusions: The results of the present study suggest that menstruation disorders are frequently observed in women taking antidepressants and that it appears to be associated with antidepressant use at least in some women.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Ambulatory Care
  • Antidepressive Agents / adverse effects*
  • Cross-Sectional Studies
  • Cyclohexanols / adverse effects
  • Female
  • Humans
  • Menstruation Disturbances / chemically induced*
  • Menstruation Disturbances / epidemiology
  • Mianserin / adverse effects
  • Mianserin / analogs & derivatives
  • Mirtazapine
  • Paroxetine / adverse effects
  • Qualitative Research
  • Sertraline / adverse effects
  • Turkey / epidemiology
  • Venlafaxine Hydrochloride
  • Young Adult


  • Antidepressive Agents
  • Cyclohexanols
  • Mianserin
  • Paroxetine
  • Venlafaxine Hydrochloride
  • Mirtazapine
  • Sertraline