Joint impact of physical activity and family history on the development of diabetes among urban adults in Mainland China: a pooled analysis of community-based prospective cohort studies

Asia Pac J Public Health. 2015 Mar;27(2):NP372-81. doi: 10.1177/1010539512443700. Epub 2012 Apr 24.


To examine the joint influences of physical activity (PA) and family history (FH) of diabetes on subsequent type 2 diabetes (T2D), the authors pooled and analyzed data from 2 community-based urban adult prospective cohort studies in 2011 in Nanjing, China. Among 4550 urban participants, the 3-year cumulative incidence of T2D was 5.1%. After adjustment for potential confounders, compared with those with FH+ and insufficient PA, the adjusted odds ratio (95% confidence interval) of developing T2D was 0.42 (0.18, 0.98) for participants with sufficient PA and FH+, 0.32 (0.22, 0.46) for participants with insufficient PA and FH-, and 0.15 (0.08, 0.28) for participants with sufficient PA and FH-. Such significant graduated associations between PA/FH and risk of developing T2D were also identified in either men or women, separately. Sufficient PA and FH- may jointly reduce the risk of developing T2D in urban Chinese adults.

Keywords: China; cohort study; family history of diabetes; physical activity; type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian Continental Ancestry Group
  • China / epidemiology
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Family Health*
  • Female
  • Humans
  • Incidence
  • Joint Diseases*
  • Male
  • Motor Activity*
  • Prospective Studies
  • Surveys and Questionnaires
  • Urban Population*