Genomic comparison between a virulent type A1 strain of Francisella tularensis and its attenuated O-antigen mutant

J Bacteriol. 2012 May;194(10):2775-6. doi: 10.1128/JB.00152-12.


We report the complete genome sequences of TI0902, a highly virulent type A1 strain, and TIGB03, a related, attenuated chemical mutant strain. Compared to the wild type, the mutant strain had 45 point mutations and a 75.9-kb duplicated region that had not been previously observed in Francisella species.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Francisella tularensis / classification
  • Francisella tularensis / genetics*
  • Francisella tularensis / pathogenicity*
  • Genome, Bacterial*
  • Molecular Sequence Data
  • Mutation
  • O Antigens / genetics*
  • Virulence


  • O Antigens

Associated data

  • GENBANK/CP003048
  • GENBANK/CP003049