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. 2012:2012:876458.
doi: 10.1155/2012/876458. Epub 2012 Mar 28.

Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts

Affiliations

Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts

Khalijah Awang et al. J Biomed Biotechnol. 2012.

Abstract

The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.

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Figures

Figure 1
Figure 1
Chemical structure of compounds 1–5.
Figure 2
Figure 2
The effects of diterpenoids isolated from the dichloromethane extract of A. paniculata, sodium nitroprusside (SNP), and 40% EtOH, on coronary perfusion pressure of isolated rat hearts. The results are expressed as mean ± s.e.m., *P < 0.05, student's paired t-test, compounds versus vehicle (40% ethanol), n = 7. Basal coronary perfusion pressure = 72.1 ± 5.6 mm Hg.
Figure 3
Figure 3
The effects of diterpenoids isolated from the dichloromethane extract of A. paniculata, 40% EtOH and isoprenaline on developed tension of isolated rat hearts. The results are expressed as mean ± s.e.m, n = 7. Basal developed tension = 3.9 ± 0.3 g.
Figure 4
Figure 4
The effects of diterpenoids isolated from the dichloromethane extract of A. paniculata, 40% EtOH and isoprenaline on heart rate (beats/min) of isolated rat hearts. The results are expressed as mean ± s.e.m, n = 7. Basal heart rate =  251 ± 13  beats/min.

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