Pharmacokinetics of midazolam in critically ill neonates

Eur J Clin Pharmacol. 1990;39(2):191-2. doi: 10.1007/BF00280059.


Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and children. An IV bolus of midazolam 0.2 was administered to 10 critically ill neonates receiving intensive care who required sedation. The plasma clearance was 6.85 ml.min-1 and the elimination half-life was 6.52 h. Midazolam was well tolerated during and after administration. Because of its short half-life compared to diazepam, midazolam could be used during the neonatal period to produce brief rapid sedation.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Critical Care
  • Diazepam / pharmacokinetics
  • Half-Life
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / metabolism*
  • Midazolam / pharmacokinetics*
  • Respiratory Distress Syndrome, Newborn / metabolism


  • Diazepam
  • Midazolam