Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial

Int J Food Sci Nutr. 2012 Nov;63(7):767-71. doi: 10.3109/09637486.2012.665043. Epub 2012 Apr 26.

Abstract

Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. Eighty-one patients were randomly assigned to receive 10 g/d BSP (A, n = 27), 5 g/d BSP (B, n = 29) and placebo (C, n = 25) for 4 weeks. Fasting serum glucose and insulin concentration, glucose to insulin ratio and homoeostasis model assessment of IR (HOMA-IR) index were measured at baseline and again 4 weeks after treatment. Seventy-two patients completed the study and 63 were included in the analysis. After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / administration & dosage
  • Antioxidants / adverse effects
  • Antioxidants / analysis
  • Antioxidants / therapeutic use*
  • Blood Glucose / analysis
  • Brassica / chemistry*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Dietary Supplements* / adverse effects
  • Dietary Supplements* / analysis
  • Double-Blind Method
  • Female
  • Humans
  • Hyperglycemia / etiology
  • Hyperglycemia / prevention & control
  • Hyperinsulinism / etiology
  • Hyperinsulinism / prevention & control
  • Insulin / blood
  • Insulin Resistance*
  • Iran
  • Isothiocyanates / administration & dosage
  • Isothiocyanates / adverse effects
  • Isothiocyanates / analysis
  • Isothiocyanates / therapeutic use
  • Male
  • Middle Aged
  • Patient Compliance
  • Patient Dropouts
  • Plant Shoots / chemistry*

Substances

  • Antioxidants
  • Blood Glucose
  • Insulin
  • Isothiocyanates
  • sulforafan