[A comparative study of the toxic and therapeutic effects of digoxin and its immobilized form]

Farmakol Toksikol. Sep-Oct 1990;53(5):37-9.
[Article in Russian]

Abstract

It was shown on different species of laboratory animals (frogs, mice, rats) that digoxin immobilized on the copolymer was 8-15 times less toxic that its usual preparation. In this case glycoside fixed on the copolymer preserves completely its specific cardiotonic effect, i.e., possesses a wider range of the therapeutic action.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Delayed-Action Preparations
  • Digoxin / administration & dosage*
  • Digoxin / therapeutic use
  • Digoxin / toxicity
  • Drug Evaluation, Preclinical
  • Electric Stimulation
  • Epinephrine
  • In Vitro Techniques
  • Lethal Dose 50
  • Male
  • Mice
  • Myocardial Contraction / drug effects
  • Myocarditis / chemically induced
  • Myocarditis / drug therapy
  • Physical Exertion / drug effects
  • Rana temporaria
  • Rats
  • Stimulation, Chemical

Substances

  • Delayed-Action Preparations
  • Digoxin
  • Epinephrine