Homologous recombination: how RecA finds the perfect partner

Curr Biol. 2012 Apr 24;22(8):R275-8. doi: 10.1016/j.cub.2012.03.002.

Abstract

How do two identical DNA sequences find each other during homologous recombination, amidst a 'sea' of unrelated DNA? New studies reveal how RecA promotes the search for homology by sampling DNA in three dimensions.

MeSH terms

  • DNA
  • Homologous Recombination*
  • Rec A Recombinases / metabolism*
  • Sequence Homology, Nucleic Acid*

Substances

  • DNA
  • Rec A Recombinases