Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria

Anaerobe. 2012 Jun;18(3):369-72. doi: 10.1016/j.anaerobe.2012.04.001. Epub 2012 Apr 17.

Abstract

Linalool and α-terpineol exhibited strong antimicrobial activity against periodontopathic and cariogenic bacteria. However, their concentration should be kept below 0.4 mg/ml if they are to be used as components of toothpaste or gargling solution. Moreover, other compounds with antimicrobial activity against periodontopathic and cariogenic bacteria should be used in combination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclic Monoterpenes
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / toxicity
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cyclohexane Monoterpenes
  • Cyclohexenes / pharmacology*
  • Cyclohexenes / toxicity
  • Dental Caries / microbiology
  • Drug Evaluation, Preclinical
  • Fusobacterium / drug effects
  • Humans
  • Microbial Sensitivity Tests
  • Monoterpenes / pharmacology*
  • Monoterpenes / toxicity
  • Oils, Volatile / pharmacology*
  • Oils, Volatile / toxicity
  • Pasteurellaceae / drug effects
  • Periodontal Diseases / microbiology
  • Porphyromonas / drug effects
  • Prevotella / drug effects
  • Streptococcus mutans / drug effects
  • Streptococcus sobrinus / drug effects

Substances

  • Acyclic Monoterpenes
  • Anti-Bacterial Agents
  • Cyclohexane Monoterpenes
  • Cyclohexenes
  • Monoterpenes
  • Oils, Volatile
  • alpha-terpineol
  • linalool