Reduced sulfate plasma concentrations in the BTBR T+tf/J mouse model of autism

Physiol Behav. 2012 Dec 5;107(5):663-5. doi: 10.1016/j.physbeh.2012.04.010. Epub 2012 Apr 17.


Clinical studies have shown that children diagnosed with autism show abnormal sulfate chemistry, which is critical for cellular and metabolic processes. To determine if the inbred BTBR T+tf/J mouse shows autism-relevant aberrations in sulfate chemistry, the present study examined plasma sulfate concentrations in BTBR T+tf/J, inbred C57BL/6J, and outbred CD-1 mice. Results showed that the BTBR T+tf/J mouse exhibits significantly lower plasma sulfate concentrations in comparison to both C57BL/6J and CD-1 mice. These results suggest that the BTBR mouse shows autism-relevant abnormalities in sulfate chemistry and may serve additional utility in examining the role of sulfate and sulfate-dependent systems in relation to autism-relevant behavioral aberrations.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Autistic Disorder / blood*
  • Disease Models, Animal
  • Male
  • Mice
  • Mice, Inbred C57BL / blood
  • Mice, Inbred Strains / blood
  • Sulfates / blood*


  • Sulfates