Sodium methoxide: a simple but highly efficient catalyst for the direct amidation of esters

Chem Commun (Camb). 2012 Jun 4;48(44):5434-6. doi: 10.1039/c2cc32153j. Epub 2012 Apr 27.

Abstract

A simple NaOMe catalyst provides superior accessibility to a wide variety of functionalized amides including peptides through direct amination of esters in an atom-economical and environmentally benign way.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amination
  • Catalysis
  • Esters / chemistry
  • Green Chemistry Technology*
  • Methanol / chemistry*
  • Peptides / chemistry

Substances

  • Amides
  • Esters
  • Peptides
  • Methanol