Rupatadine 10 mg in the treatment of immediate mosquito-bite allergy

J Eur Acad Dermatol Venereol. 2012 Jul;26(7):919-22. doi: 10.1111/j.1468-3083.2012.04543.x. Epub 2012 Apr 28.


Background: People frequently experience wealing and delayed papules from mosquito bites. Wealing is mediated by antisaliva IgE antibodies and histamine. Rupatadine is a new antihistamine effective in allergic rhinitis and urticaria, but the effect on mosquito-bite allergy is not known.

Objective: To determine the effectiveness of rupatadine in inmediate mosquito-bite allergy-confirmed adult patients.

Methods: A double-blind, placebo-controlled, cross-over study was performed with rupatadine 10 mg and matched placebo in 30 mosquito-bite-sensitive adults. The mean age was 37 years and the subjects had suffered from harmful mosquito bites for a mean of 15 years. Either rupatadine or placebo was taken at 08:00 am for 4 days, followed by a 5 day wash out period and then alternative treatment was given for 4 days. On day 3, in both drug periods the subjects received two Aedes aegypti mosquito-bites on the forearm. The size of lesions and intensity of pruritus [visual analogue scale (VAS)] were measured after 15 min bite reaction.

Results: Twenty-six subjects were analysed for efficacy. The size of the 15 min bite reaction under placebo was of 106 mm2 and under rupatadine, of 55 mm2. This is a significant decrease (48%; P=0.0003). The accompanying pruritus decreased from 60 (VAS; median) under placebo to 47.5 under rupatadine, which also is a significant (P=0.019) difference. There was no significant (P=0.263) difference in adverse events under rupatadine and placebo.

Conclusion: The present placebo-controlled study in mosquito-bite-sensitive adults shows that rupatadine 10 mg prophylactically given is an effective treatment for the mosquito-bite wealing and skin pruritus.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aedes*
  • Animals
  • Cross-Over Studies
  • Cyproheptadine / analogs & derivatives*
  • Cyproheptadine / therapeutic use
  • Double-Blind Method
  • Histamine H1 Antagonists / therapeutic use
  • Humans
  • Insect Bites and Stings / drug therapy*
  • Insect Bites and Stings / immunology
  • Insect Bites and Stings / physiopathology
  • Middle Aged
  • Placebos
  • Pruritus / drug therapy
  • Pruritus / physiopathology


  • Histamine H1 Antagonists
  • Placebos
  • rupatadine
  • Cyproheptadine