Seroprevalence of anti-Toxoplasma gondii IgG antibody in patients with schizophrenia

Trop Biomed. 2012 Mar;29(1):151-9.


Schizophrenia is a pervasive neuropsychiatric disease of unknown cause. Previous studies have reported that toxoplasmosis may be a possible cause of schizophrenia. To ascertain possible relationship between Toxoplasma gondii and schizophrenia, a cross sectional study, employing an enzyme-linked immunosorbent assay (ELISA) was performed to study the seroprevalence of anti-T. gondii IgG antibody in schizophrenic patients. Furthermore, demographic data analysis from schizophrenic patients were analysed to associate toxoplasmosis with schizophrenia. A total of 288 serum samples from schizophrenic patients (n=144) and psychiatrically healthy volunteers (n=144) were recruited in this study. Interestingly, a significant result in the serointensity rate of anti-T. gondii IgG antibody (> 60 IU/mL) in schizophrenic patients (61.1%) was demonstrated as compared to psychiatrically healthy volunteers (40.8%) (X² = 4.236, p < 0.050). However, there was no significant difference between the seropositivity rate of anti-T. gondii IgG antibody between the two groups. Analysis from demographic data revealed that the seropositivity rate of anti-T. gondii IgG antibody in schizophrenic patients was significantly associated with age group of more than 40 years old (p=0.007) and between ethnic (p=0.046). Nevertheless, no significant association between seropositivity rate of anti-T. gondii IgG antibody with gender (p=0.897), duration of illness (p=0.344) and family history of schizophrenia (p=0.282) in these patients. Thus, this finding is essential as a preliminary data in Malaysia to establish the association between T. gondii and schizophrenia.

MeSH terms

  • Adult
  • Age Factors
  • Animals
  • Antibodies, Protozoan / blood*
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay
  • Ethnicity
  • Female
  • Humans
  • Immunoglobulin G / blood*
  • Malaysia / epidemiology
  • Male
  • Middle Aged
  • Risk Factors
  • Schizophrenia / complications*
  • Seroepidemiologic Studies
  • Toxoplasma / immunology*
  • Toxoplasmosis / epidemiology*


  • Antibodies, Protozoan
  • Immunoglobulin G