Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer's disease: a meta-analysis

J Alzheimers Dis. 2012;31(2):253-8. doi: 10.3233/JAD-2012-120349.


In view of the vital role of oxidative stress in the pathogenesis of Alzheimer's disease (AD), the potential of antioxidant supplements to prevent AD have gained much interest, while there are conflicting results on this topic in recent years. The purpose of the present study is to comprehensively evaluate the association between dietary intakes, instead of supplements, of the most common three antioxidants (vitamin E, vitamin C, and β-carotene) and the risk of AD on the basis of the meta-analysis studies published up to October 2011 in Medline and Scopus databases. In total, seven articles were included in the meta-analysis. According to the pooled relative risk [(95% CI) 0.76 (0.67-0.84) for vitamin E, 0.83 (0.72-0.94) for vitamin C, and 0.88 (0.73-1.03) for β-carotene], dietary intakes of the three antioxidants can lower the risk of AD, with vitamin E exhibiting the most pronounced protective effects. The findings will be of significance to the prevention and interventional treatment of AD.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / diet therapy
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / prevention & control*
  • Antioxidants / administration & dosage
  • Ascorbic Acid / administration & dosage*
  • Dietary Supplements*
  • Humans
  • Oxidative Stress / drug effects
  • Oxidative Stress / physiology
  • Risk Factors
  • Vitamin E / administration & dosage*
  • beta Carotene / administration & dosage*


  • Antioxidants
  • beta Carotene
  • Vitamin E
  • Ascorbic Acid