Survival benefit of early infant antiretroviral therapy is compromised when diagnosis is delayed

Pediatr Infect Dis J. 2012 Jul;31(7):729-31. doi: 10.1097/INF.0b013e3182587796.

Abstract

Late presentation is common among African HIV-1-infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by 5 months of age. Twelve-month survival was 66.8% (95% confidence interval: 55.9-75.6%). World Health Organization stage 3 or 4, underweight, wasting, microcephaly, low hemoglobin, pneumonia and gastroenteritis predicted mortality. Early HIV-1 diagnosis with antiretroviral therapy before symptomatic disease is critical for infant survival.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-HIV Agents / administration & dosage*
  • Antiretroviral Therapy, Highly Active / methods*
  • Delayed Diagnosis
  • Female
  • HIV Infections / diagnosis*
  • HIV Infections / drug therapy*
  • HIV Infections / mortality
  • HIV Infections / virology
  • HIV-1 / isolation & purification
  • Humans
  • Infant
  • Male
  • Survival Analysis

Substances

  • Anti-HIV Agents