ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways

Cell Cycle. 2012 May 15;11(10):1977-87. doi: 10.4161/cc.20309. Epub 2012 May 15.

Abstract

RNA binding proteins belonging to the TIS11/TTP gene family regulate the stability of multiple targets. Their inactivation or deregulated expression has recently been related to cancer, and it has been suggested that they are capable of displaying tumor suppressor activities. Here we describe three new targets of ZFP36 (PIM-1, PIM-3 and XIAP) and show by different approaches that its ectopic expression is capable of impairing glioblastoma cell lines viability and invasiveness by interfering with different transduction pathways. Moreover, we provide evidence that compounds capable of inducing the expression of TIS11/TTP genes determine a comparable biological effect on the same cell contexts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Cell Movement
  • Cell Survival
  • Fungal Proteins
  • Glioblastoma / metabolism
  • Glioblastoma / pathology
  • HEK293 Cells
  • Humans
  • Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / metabolism
  • Polyphenols / pharmacology
  • Protein Binding
  • Protein Serine-Threonine Kinases / antagonists & inhibitors
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins / antagonists & inhibitors
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism
  • RNA Interference
  • RNA, Small Interfering / metabolism
  • Signal Transduction*
  • Tristetraprolin / genetics
  • Tristetraprolin / metabolism*
  • X-Linked Inhibitor of Apoptosis Protein / antagonists & inhibitors
  • X-Linked Inhibitor of Apoptosis Protein / genetics
  • X-Linked Inhibitor of Apoptosis Protein / metabolism

Substances

  • 3' Untranslated Regions
  • Fungal Proteins
  • Polyphenols
  • Proto-Oncogene Proteins
  • RNA, Small Interfering
  • Tristetraprolin
  • X-Linked Inhibitor of Apoptosis Protein
  • ZFP36 protein, human
  • PIM3 protein, human
  • Protein Serine-Threonine Kinases
  • Mitogen-Activated Protein Kinases
  • Pim1 protein, Pichia pastoris