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. 2012 Mar;7(3):293-4.

Two new antimicrobial metabolites from the endophytic fungus, Seimatosporium sp

Affiliations
  • PMID: 22545398

Two new antimicrobial metabolites from the endophytic fungus, Seimatosporium sp

Hidayat Hussain et al. Nat Prod Commun. 2012 Mar.

Abstract

Two new acaranoic acids, named seimatoporic acid A and B (1, and 2), together with six known compounds, R-(-)-mellein (3), cis-4-hydroxymellein (4), trans-4-hydroxymellein (5), 4R-hydroxy-5-methylmellein (6), (-)-5-hydroxymethylmellein (7), and ergosterol (8) were isolated from an endophytic fungus, Seimatosporium sp, by a bioassay-guided procedure. The structures of the new compounds have been assigned from analysis of the 1H and 13C NMR spectra, DEPT, and by 2D COSY, HMQC, HMBC and NOESY experiments. A mixture of compounds 1 and 2 showed strong antifungal activity against Botrytis cinerea, Septoria tritici, and Pyricularia oryzae.

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