Genetic testing in domestic cats

Mol Cell Probes. 2012 Dec;26(6):224-30. doi: 10.1016/j.mcp.2012.04.004. Epub 2012 Apr 21.


Varieties of genetic tests are currently available for the domestic cat that support veterinary health care, breed management, species identification, and forensic investigations. Approximately thirty-five genes contain over fifty mutations that cause feline health problems or alterations in the cat's appearance. Specific genes, such as sweet and drug receptors, have been knocked-out of Felidae during evolution and can be used along with mtDNA markers for species identification. Both STR and SNP panels differentiate cat race, breed, and individual identity, as well as gender-specific markers to determine sex of an individual. Cat genetic tests are common offerings for commercial laboratories, allowing both the veterinary clinician and the private owner to obtain DNA test results. This article will review the genetic tests for the domestic cat, and their various applications in different fields of science. Highlighted are genetic tests specific to the individual cat, which are a part of the cat's genome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cat Diseases / diagnosis*
  • Cat Diseases / genetics
  • Cats
  • DNA Mutational Analysis
  • Genetic Testing*
  • Genome
  • Humans
  • Molecular Diagnostic Techniques
  • Mutation
  • Pedigree
  • Pets / genetics*
  • Phenotype