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, 22 (11), 3751-3

Wake Promoting Agents: Search for Next Generation Modafinil, Lessons Learned: Part III

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Wake Promoting Agents: Search for Next Generation Modafinil, Lessons Learned: Part III

Derek Dunn et al. Bioorg Med Chem Lett.

Abstract

In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).

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