[Essential hypertension - which genes can be held responsible for it?]

Ther Umsch. 2012 May;69(5):273-8. doi: 10.1024/0040-5930/a000285.
[Article in German]


Hypertension is a common heritable cardiovascular risk factor. Some rare monogenic forms of hypertension have been described, but the majority of patients suffer from essential hypertension, for whom the underlying genetic mechanisms are not clear. Essential hypertension is a complex trait, involving multiple genes and environmental factors. Recently, progress in the identification of common genetic variants associated with essential hypertension has been made due to large-scale international collaborative projects. In this article we review the new research methods used as well as selected recent findings in this field.

Publication types

  • English Abstract

MeSH terms

  • Cardiovascular Diseases / genetics
  • Gene-Environment Interaction
  • Genome-Wide Association Study
  • Humans
  • Hypertension / genetics*
  • Multifactorial Inheritance / genetics*
  • Risk Factors