The meaning of mitochondrial movement to a neuron's life

Biochim Biophys Acta. 2013 Jan;1833(1):184-94. doi: 10.1016/j.bbamcr.2012.04.007. Epub 2012 Apr 21.


Cells precisely regulate mitochondrial movement in order to balance energy needs and avoid cell death. Neurons are particularly susceptible to disturbance of mitochondrial motility and distribution due to their highly extended structures and specialized function. Regulation of mitochondrial motility plays a vital role in neuronal health and death. Here we review the current understanding of regulatory mechanisms that govern neuronal mitochondrial transport and probe their implication in health and disease. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Disease / etiology
  • Humans
  • Mitochondria / metabolism
  • Mitochondria / physiology*
  • Mitochondrial Dynamics / physiology
  • Models, Biological
  • Movement / physiology*
  • Neurons / physiology*
  • Neurons / ultrastructure