Future developments to minimize ART risks

Semin Reprod Med. 2012 Apr;30(2):152-60. doi: 10.1055/s-0032-1307423. Epub 2012 Apr 27.


The most important complications of assisted reproductive techniques are the risk of ovarian hyperstimulation syndrome (OHSS) and the high incidence of multiple pregnancies. Two new strategies are effective in preventing OHSS: the use of anti-müllerian hormone as a marker and the use of dopamine agonists. Genetic markers and vascular endothelial growth factor levels do not predict OHSS. In vitro oocyte maturation treatment should be considered in high responders and in women at risk of OHSS. For prevention of multiple pregnancies, the most effective method is transfer of a single embryo. Preimplantation genetic screening with comparative genomic hybridization, genetic expression of cumulus cells, time-lapse imaging, and respiration rate are emerging technologies for embryo selection that require further study.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Mullerian Hormone / blood
  • Anti-Mullerian Hormone / physiology
  • Cytokines / blood
  • Dopamine Agonists / adverse effects
  • Dopamine Agonists / therapeutic use
  • Female
  • Gene Expression / physiology
  • Genetic Markers
  • Genetic Testing
  • Gonadotropins / adverse effects
  • Gonadotropins / therapeutic use
  • Humans
  • Ovarian Hyperstimulation Syndrome / drug therapy
  • Ovarian Hyperstimulation Syndrome / etiology*
  • Ovarian Hyperstimulation Syndrome / genetics
  • Ovarian Hyperstimulation Syndrome / physiopathology
  • Ovarian Hyperstimulation Syndrome / prevention & control
  • Pregnancy
  • Pregnancy, Multiple / genetics
  • Pregnancy, Multiple / physiology
  • Rats
  • Reproductive Techniques, Assisted / adverse effects*
  • Risk


  • Cytokines
  • Dopamine Agonists
  • Genetic Markers
  • Gonadotropins
  • Anti-Mullerian Hormone