Senescence in chronic obstructive pulmonary disease

Proc Am Thorac Soc. 2012 May;9(2):62-3. doi: 10.1513/pats.201201-012MS.


There is a growing realization that chronic obstructive pulmonary disease involves several processes present in aging and cellular senescence. The impact of these processes in the pathogenesis of the main manifestations is multiple, particularly in the propagation of a proinflammatory phenotype, loss of reparative potential, and amplification of oxidative stress, all ultimately leading to tissue damage. This review highlights salient aspects related to senescence discussed in the 2011 Aspen Lung Conference.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cellular Senescence / immunology*
  • Humans
  • Lung* / immunology
  • Lung* / metabolism
  • Oxidative Stress / immunology*
  • Pulmonary Disease, Chronic Obstructive / immunology*
  • Pulmonary Disease, Chronic Obstructive / metabolism*