Relationship between bacterial load, morbidity and cagA gene in patients infected by Helicobacter pylori

Clin Microbiol Infect. 2012 Jul;18(7):E251-3. doi: 10.1111/j.1469-0691.2012.03884.x. Epub 2012 May 2.


One hundred and seventy-six biopsies of the gastric corpus and antrum from 97 patients were processed using classical and molecular methods in order to study the relationship between the factor cagA of Helicobacter pylori, bacterial load and morbidity. Bacterial load in patients with cagA was greater than in patients without it, both in the antrum and corpus (p<0.01). There was a statistically significant association between cagA and consumption of proton pump inhibitors (adjusted odds ratio 3.11). Haemorrhage of the upper digestive tract was more associated with bacterial load than with the cagA gene (adjusted odds ratio 2.34 and 1.12, respectively), but none of these associations yielded statistical significance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antigens, Bacterial / genetics*
  • Bacterial Load*
  • Bacterial Proteins / genetics*
  • Biopsy
  • Drug Utilization / statistics & numerical data
  • Female
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology
  • Gastrointestinal Hemorrhage / epidemiology
  • Helicobacter Infections / microbiology*
  • Helicobacter Infections / pathology*
  • Helicobacter pylori / genetics*
  • Helicobacter pylori / pathogenicity*
  • Humans
  • Male
  • Middle Aged
  • Proton Pump Inhibitors / therapeutic use
  • Virulence Factors / genetics*


  • Antigens, Bacterial
  • Bacterial Proteins
  • Proton Pump Inhibitors
  • Virulence Factors
  • cagA protein, Helicobacter pylori