CSA: comprehensive comparison of pairwise protein structure alignments

Nucleic Acids Res. 2012 Jul;40(Web Server issue):W303-9. doi: 10.1093/nar/gks362. Epub 2012 May 2.


CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Calmodulin / chemistry
  • Internet
  • Software*
  • Structural Homology, Protein*


  • Calmodulin