The safety of postmenopausal testosterone therapy

Womens Health (Lond). 2012 May;8(3):263-75. doi: 10.2217/whe.12.11.


Testosterone is increasingly used as part of postmenopausal HRT regimens. Unfortunately, few androgenic preparations designed specifically for use in women have been approved by regulatory authorities. Ongoing concerns exist surrounding the potential long-term effects of testosterone therapy. Here, we review the most recent data on postmenopausal testosterone therapy, focusing particularly on the effects of testosterone on breast, endometrium and cardiovascular health.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Androgens / physiology
  • Endometrium / drug effects
  • Estrogen Replacement Therapy*
  • Female
  • Humans
  • Postmenopause*
  • Risk Factors
  • Testosterone / adverse effects
  • Testosterone / therapeutic use*


  • Androgens
  • Testosterone